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Medical News and Perspectives
March 9, 2005

Molecular Switch Triggers Fats’ Harm

JAMA. 2005;293(10):1180. doi:10.1001/jama.293.10.1180

Most people know consuming fatty foods can have negative health effects. Now, researchers studying rats and mice have identified the molecular mechanism by which saturated and trans-fats trigger a rise in blood cholesterol and triglycerides, increasing the risk of cardiovascular disease (Lin et al. Cell. 2005;120:261-273).

The molecular players in this scenario are also found in humans. Although it remains to be seen whether the results will have clinical relevance, pharmaceutical companies have already expressed interest in the implications of the new findings for treating individuals with elevated blood cholesterol levels.

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