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March 16, 2005

Estrogen Plus Progestin and Risk of Venous Thrombosis—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293(11):1322-1323. doi:10.1001/jama.293.11.1322-c

In Reply: Dr Scarabin and colleagues raise the possibility that transdermal and oral estrogens differ in their association with venous thrombosis. In their case-control study of venous thromboembolism, 30 cases and 93 controls used transdermal estrogen, and no association of transdermal therapy with thrombosis was found.1 This study, as well as all others addressing this question, included only hospitalized women with idiopathic thrombosis and without a history of coronary heart disease and other illnesses. The 3 other published studies had small numbers of users, but all suggested a 2-fold increased thrombosis risk with transdermal estrogen.24

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