To spur healing following an injury, many genes are called into action
to promote matrix remodeling, cell motility, and angiogenesis. While these
processes are all well and good for the recruitment of blood, cells, and nutrients
needed to repair damaged tissue, they can be hijacked by tumors to promote
malignant invasion and metastasis.
“There are a lot of interesting parallels between cancer progression
and the normal process of wound healing,” said Patrick Brown, MD, PhD,
of the Stanford University School of Medicine, in Stanford, Calif.
Hampton T. Genes That Heal Body Co-opted by Breast Tumor to Promote Cancer’s Spread. JAMA. 2005;293(11):1309-1310. doi:10.1001/jama.293.11.1309