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Medical News and Perspectives
March 16, 2005

Genes That Heal Body Co-opted by Breast Tumor to Promote Cancer’s Spread

JAMA. 2005;293(11):1309-1310. doi:10.1001/jama.293.11.1309

To spur healing following an injury, many genes are called into action to promote matrix remodeling, cell motility, and angiogenesis. While these processes are all well and good for the recruitment of blood, cells, and nutrients needed to repair damaged tissue, they can be hijacked by tumors to promote malignant invasion and metastasis.

“There are a lot of interesting parallels between cancer progression and the normal process of wound healing,” said Patrick Brown, MD, PhD, of the Stanford University School of Medicine, in Stanford, Calif.

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