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Medical News and Perspectives
March 16, 2005

Implications of Halted Study’s Findings for Hypertension Guidelines Unclear

JAMA. 2005;293(11):1312-1315. doi:10.1001/jama.293.11.1312

Unpublished findings from a recently halted hypertension treatment trial has left some experts calling for changes to current guidelines for the control of high blood pressure and others preaching caution about making such changes until a detailed analysis of the new data is completed.

The source of the dispute is data from the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), which was halted in December at the recommendation of the trial’s independent data safety monitoring board when an interim analysis of the data found that a newer treatment strategy of amlodipine (a calcium channel blocker) and perindopril (an angiotensin-converting enzyme inhibitor) was superior to the older treatment regimen of atenolol (a β-blocker) and bendroflumethiazide (a thiazide diuretic).

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