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Books, Journals, New Media
April 6, 2005


Author Affiliations

Books, Journals, New Media Section Editor: Harriet S. Meyer, MD, Contributing Editor, JAMA; Journal Review Editor: Brenda L. Seago, MLS, MA, Medical College of Virginia Campus, Virginia Commonwealth University.

JAMA. 2005;293(13):1671-1676. doi:10.1001/jama.293.13.1671-a

In the 10 years since the release of the second edition of Myology, there have been an incredible number of discoveries with huge effect on the field of myology. Important among them have been the sequencing of the human genome and the widespread use of molecular and other techniques, including microarrays, siRNA (short interfering RNA), proteomics, and metabolomics, to name a few.

Some of the most dramatic of those advances are well documented in the third edition of Myology, including further understanding of nuclear RNA sequestration in myotonic dystrophy type 1, the huge proliferation of the number of known nuclear DNA mutations responsible for mitochondrial cytopathies, identification of a large number of protein mutations responsible for the limb girdle muscular dystrophies, recognition and understanding of the nuclear envelope–related myopathies, identification of a number of mutations responsible for congenital muscular dystrophy, and deeper understanding of the role of the extracellular matrix in a variety of myopathies.

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