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April 6, 2005

Cardiovascular Risk Stratification in Older PatientsRole of Brain Natriuretic Peptide, C-Reactive Protein, and Urinary Albumin Levels

Author Affiliations

Author Affiliation: Department of Internal Medicine, University of Vienna, Medical School, Vienna, Austria.

JAMA. 2005;293(13):1667-1669. doi:10.1001/jama.293.13.1667

Cardiovascular risk prediction by noninvasive laboratory testing in the general population is becoming increasingly recognized as an important health care issue. During the last decade, a variety of novel potentially powerful prognostic biomarkers emerged, which may yield prognostic information even in individuals without evidence of prevalent disease. Among the panel of promising parameters, the role of natriuretic peptides and inflammatory markers has been extensively studied in various populations and clinical settings. Natriuretic peptides have been shown to predict outcome of patients with heart failure, coronary artery, and valvular heart disease.14 However, unlike studies examining C-reactive protein (CRP),57 investigations of natriuretic peptides in predicting future cardiovascular events have not been conducted in population-based samples, and comparative analyses including a variety of prognostic biomarkers are scarce.5,8

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