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April 13, 2005

Lead Exposure and Cataract Risk in Men

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293(14):1724-1725. doi:10.1001/jama.293.14.1724-b

To the Editor: The study by Dr Schaumberg and colleagues1 controlled for a number of variables; however, there are 2 important potential confounders that were not addressed. First, while a specific gene has not been identified in cataractogenesis, Heiba et al2 used sibling correlations to conclude that there could be a major gene responsible for the formation of nuclear cataracts. Research by Hammond et al3 also supports the possibility of a genetic effect in the development of nuclear cataracts by proposing that dominant genes may be involved in this process.

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