Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
To the Editor: The study by Dr Schaumberg and
colleagues1 controlled for a number of variables;
however, there are 2 important potential confounders that were not addressed.
First, while a specific gene has not been identified in cataractogenesis,
Heiba et al2 used sibling correlations to conclude
that there could be a major gene responsible for the formation of nuclear
cataracts. Research by Hammond et al3 also
supports the possibility of a genetic effect in the development of nuclear
cataracts by proposing that dominant genes may be involved in this process.
Song BJ. Lead Exposure and Cataract Risk in Men. JAMA. 2005;293(14):1724-1725. doi:10.1001/jama.293.14.1724-b