Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
In Reply: Dr Beebe and Mr Song express concern
that our finding of a 3-fold increased risk of cataract associated with increased
tibia lead levels in men may be confounded by socioeconomic status, family
history of cataract, or BMI. Among studies that have shown these factors to
be associated with cataract, the highest risk estimates have been around a
2-fold increase.1- 3 Given
the magnitude of our findings, it is unlikely that controlling for these factors
would eliminate the strong association between tibia lead and cataract we
observed. Although we did not assess data on family history of cataract, we
believe it unlikely that any association between family history of cataract
and tibia lead levels would be strong enough to result in significant confounding.
Schaumberg DA, Hu H. Lead Exposure and Cataract Risk in Men—Reply. JAMA. 2005;293(14):1724-1725. doi:10.1001/jama.293.14.1724-c