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JAMA 100 Years Ago
April 20, 2005

DIPHTHERIA ANTITOXIN IN THE TREATMENT OF GOITER.

JAMA. 2005;293(15):1854. doi:10.1001/jama.293.15.1854

ROBERT T. LEGGE, PH.G., M.D.
MCCLOUD, CAL
.

During the summer of 1903 I had occasion to treat a family with Diphtheria; one patient died from the laryngeal form after tracheotomy had been performed and large doses of antitoxin had been administered. An aunt acted as a nurse; she has exophthalmic goiter, with all the classic symptoms. No immunizing dose of antitoxin was given her, and she was infected with moderately severe pharyngeal diphtheria. I immediately injected 1,500 units of antitoxin and repeated the dose on the following day, combined with local antiseptic and internal supportive treatment, with the result that at the end of the week she was convalescent.

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