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April 20, 2005

Urinary Placental Growth Factor and Preeclampsia

JAMA. 2005;293(15):1857-1858. doi:10.1001/jama.293.15.1857-a

To the Editor: The study by Dr Levine and colleagues1 showed that urinary placental growth factor (PlGF) was significantly lower beginning at 25 to 28 weeks of gestation among women who subsequently developed preeclampsia compared with normotensive controls. From an ancillary study, they also concluded that a low urinary PlGF concentration at 21 to 32 weeks of gestation may distinguish preeclampsia from intrauterine growth retardation in normotensive women. However, 239 women with term preeclampsia (37 weeks) were excluded from both the main and ancillary studies. It is therefore possible that many women who delivered a small-for-gestational-age (SGA) infant because of uteroplacental insufficiency were excluded because they developed the later preeclampsia that is often observed in these circumstances.2

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