A trio of studies has identified a gene variant that may be responsible
for about half of the 15 million age-related macular degeneration (AMD) cases
in the United States. The finding also suggests that inflammation plays an
important role in the etiology of the disease.
The three multi-institution studies were published in an advance online
edition of Science on March 10 (http://www.sciencexpress.org). The research, which used techniques derived from the Human Genome
Project, identified a common variant of the complement factor H (CFH) gene that explains about 50% of AMD cases.
Kuehn BM. Gene Discovery Provides Clues to Cause of Age-Related Macular Degeneration. JAMA. 2005;293(15):1841-1845. doi:10.1001/jama.293.15.1841