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Medical News and Perspectives
April 20, 2005

Gene Discovery Provides Clues to Cause of Age-Related Macular Degeneration

JAMA. 2005;293(15):1841-1845. doi:10.1001/jama.293.15.1841

A trio of studies has identified a gene variant that may be responsible for about half of the 15 million age-related macular degeneration (AMD) cases in the United States. The finding also suggests that inflammation plays an important role in the etiology of the disease.

The three multi-institution studies were published in an advance online edition of Science on March 10 (http://www.sciencexpress.org). The research, which used techniques derived from the Human Genome Project, identified a common variant of the complement factor H (CFH) gene that explains about 50% of AMD cases.

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