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April 27, 2005

Obesity and the Risk of New-Onset Atrial Fibrillation—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293(16):1974-1975. doi:10.1001/jama.293.16.1975-a

In Reply: We agree with Drs Korantzopoulos and Kolettis that inflammation is another potentially important mechanism linking obesity and AF. Cross-sectional studies1,2 have shown an association between C-reactive protein levels and AF, and a longitudinal study demonstrated that C-reactive protein levels predicted the development of AF over a mean follow-up of 7 years in the Cardiovascular Health Study cohort.3 Obese individuals may have elevated C-reactive protein levels.4 Thus, it is plausible that systemic inflammation contributes to the increased risk of AF observed in obese individuals. Because C-reactive protein levels were not routinely measured at our baseline examinations, we were unable to investigate this interesting hypothesis.

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