Two teams of researchers are providing a clearer picture of X-linked
inheritance, including some surprises in their findings that may help to explain
some medically important genetic differences between men and women, and even
On March 17, an international team of more than 200 scientists published
the results of the sequencing of 99% of the human X chromosome in Nature (Ross et al. Nature. 2005;434:325-337).
A second article in the same issue reveals that many more genes than previously
thought escape X inactivation and that the number of genes that escape inactivation
varies from woman to woman (Carrel and Willard. Nature.
Kuehn BM. Mysteries of the X Chromosome Revealed. JAMA. 2005;293(16):1961-1962. doi:10.1001/jama.293.16.1961