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Medical News and Perspectives
May 4, 2005

Heart Risk Rises With Long-term HIV Drugs

JAMA. 2005;293(17):2081. doi:10.1001/jama.293.17.2081

Boston—One emerging concern regarding long-term treatment with highly active antiretroviral therapy (HAART)—an era that begin in the mid-1990s when protease inhibitors first became available and were combined with other classes of anti-HIV drugs—has been elevation in blood lipids and the potential for increased risk of heart disease. New findings from a large observational study presented at the 12th Annual Retrovirus Conference by Wafaa El-Sadr, MD, MPH, of Columbia University’s Mailman School of Public Health in New York City, revealed that the risk of myocardial infarction (MI) increases with longer exposure to HAART.

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