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May 11, 2005

Balancing the Upside and Downside of Antiretroviral Therapy in Children

Author Affiliations

Author Affiliations: Division of Infectious Diseases, Children’s Memorial Hospital, Chicago, Ill.

JAMA. 2005;293(18):2272-2274. doi:10.1001/jama.293.18.2272

In the late 1980s part of my routine, as the director of a pediatric human immunodeficiency virus (HIV)/AIDS clinic, was to attend funerals of my patients, children who succumbed to this disease. Now I am attending their graduations from high school and some of my patients are going to college. This anecdotal observation about the dramatic impact of highly active antiretroviral treatment (HAART) on the outcome of HIV infection in children is substantiated by the results reported by Berk and colleagues1 in this issue of JAMA, which demonstrate that decreased HIV progression and improved survival of infected children are associated with early and more advanced antiretroviral therapy (ART).

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