Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
In Reply: Dr Nath and colleagues suggest that
the findings of our study are limited because we did not consider several
other risk factors for cancer in assessing the association of serum glucose
level and diabetes with cancer risk. The study data, coming from a questionnaire
and blood chemistry laboratory tests, could not cover all known risk factors
for cancer. However, such factors could confound the associations found in
the study if they are also associated with serum glucose level and presence
of diabetes. For example, dioxin in food would introduce bias only if the
intake of dioxin were associated with blood glucose level and diabetes in
our study population. We doubt that such confounding occurred, particularly
because the population came from a relatively homogeneous group of professionals
and their family members.
Jee SH, Ohrr H, Sull JW, Yun JE, Min J, Samet JM. Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women—Reply. JAMA. 2005;293(18):2210-2211. doi:10.1001/jama.293.18.2211-a