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May 11, 2005

Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293(18):2210-2211. doi:10.1001/jama.293.18.2211-a

In Reply: Dr Nath and colleagues suggest that the findings of our study are limited because we did not consider several other risk factors for cancer in assessing the association of serum glucose level and diabetes with cancer risk. The study data, coming from a questionnaire and blood chemistry laboratory tests, could not cover all known risk factors for cancer. However, such factors could confound the associations found in the study if they are also associated with serum glucose level and presence of diabetes. For example, dioxin in food would introduce bias only if the intake of dioxin were associated with blood glucose level and diabetes in our study population. We doubt that such confounding occurred, particularly because the population came from a relatively homogeneous group of professionals and their family members.

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