Two new studies by researchers in Europe and Africa indicate that combining
two antimalarial drugs, artemether plus lumefantrine, is an effective way
to treat malaria caused by drug-resistant strains of Plasmodium
In one study, researchers from England and Tanzania randomly assigned
about 1800 children with malaria to receive amodiaquine alone, amodiaquine
combined with sulfadoxine-pyrimethamine or artesunate, or artemether plus
lumefantrine (Mutabingwa et al. Lancet. 2005;365:1474-1480).
After 14 days, parasites were cleared from the blood of 99% of children who
received the artemether-lumefantrine combination compared with rates of 58%
to 89% in the other groups. After 28 days, only 3% of children who received
the artemether-lumefantrine combination had a recurrence compared with failure
rates of 12% to 49% in the other groups.
Stephenson J. Malaria Treatment. JAMA. 2005;293(19):2333. doi:10.1001/jama.293.19.2333-c