Although lumbar disc disease has long been recognized as a primary cause
of lower back pain and studies have pointed to a genetic component for its
development, its etiology and pathogenesis are largely unknown. Now, researchers
from Japan reported on May 1 in an online edition of Nature
Genetics (http://npg.nature.com/) that they have identified
a genetic variation associated with susceptibility to lumbar disc disease,
a finding that could shed light on factors that contribute to disc degeneration.
Stephenson J. Lumbar Disc Disease. JAMA. 2005;293(19):2333. doi:10.1001/jama.293.19.2333-d