Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
To the Editor: In their article on detection
of bladder cancer using a proteomic assay,1 Dr
Grossman and colleagues do not specify why the studied patients underwent
cystoscopy. It is necessary to understand the study population to judge validity
and generalizability. In particular, it would be important to know what percentage
of the patients had symptoms or signs, how many had occupational exposure,
and how many were screened solely because they were smokers. Given the absence
of standard screening recommendations based on smoking status, if this were
the basis for testing in some of these subjects I would want to know if it
was because of current or past smoking, or whether it was based on amount
smoked per day.
Louria DB. Detection of Bladder Cancer Using a Proteomic Assay. JAMA. 2005;293(20):2466-2467. doi:10.1001/jama.293.20.2466-b