Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
In Reply: Patients enrolled in the study investigating
the NMP22 assay were evaluated with cystoscopy because of the presence of
risk factors that are associated with bladder cancer. Of the 1331 individuals,
91.6% (1220/1331) had hematuria, the most common symptom of bladder cancer.
Other risk factors/symptoms included smoking, exposure to carcinogens, and
dysuria. Many patients had more than 1 factor (565/1331 [42.4%]), and none
were enrolled due to smoking history alone. The enrolling physicians believed
that the patients were at sufficient risk to be screened for bladder cancer.
Grossman HB. Detection of Bladder Cancer Using a Proteomic Assay—Reply. JAMA. 2005;293(20):2466-2467. doi:10.1001/jama.293.20.2467-b