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June 8, 2005

Continuous Positive Airway Pressure and Postoperative Hypoxemia—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293(22):2714-2715. doi:10.1001/jama.293.22.2714-b

In Reply: We agree with Drs Frangos and Schwartz that CPAP-induced recruitment of atelectasis may attenuate the spillover of inflammatory mediators from the lung to the systemic circulation1 and may have contributed to the reduction in sepsis and anastomotic leakage that we observed in the patients treated with CPAP. Unfortunately, we did not prospectively measure inflammatory mediators, protein concentration, or total body water. Further studies are required to explain the role of CPAP in preventing postoperative sepsis and anastomotic leakage.

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