Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
In Reply: We agree with Drs Frangos and Schwartz
that CPAP-induced recruitment of atelectasis may attenuate the spillover of
inflammatory mediators from the lung to the systemic circulation1 and
may have contributed to the reduction in sepsis and anastomotic leakage that
we observed in the patients treated with CPAP. Unfortunately, we did not prospectively
measure inflammatory mediators, protein concentration, or total body water.
Further studies are required to explain the role of CPAP in preventing postoperative
sepsis and anastomotic leakage.
Ranieri VM, Squadrone V. Continuous Positive Airway Pressure and Postoperative Hypoxemia—Reply. JAMA. 2005;293(22):2714-2715. doi:10.1001/jama.293.22.2714-b