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June 22/29, 2005

Infective EndocarditisGlobal, Regional, and Future Perspectives

Author Affiliations

Author Affiliation: Yale University School of Medicine, New Haven, Conn.

JAMA. 2005;293(24):3061-3062. doi:10.1001/jama.293.24.3061

Contemporary case series describing patterns of infective endocarditis date back to the Gulstonian Lectures of Osler, in which he described clinical complications, pathogenesis, and pathological features.1 With diagnostic and treatment advances over the past 50 years, recent descriptions have focused on the broad spectrum of microbial causes, an increasing array of predisposing risks, the role of bactericidal antibiotic combinations, and the impact of valve surgery on clinical outcome.25 Nonetheless, epidemiologic shifts of incidence and bacterial etiologies have been suspected because of advancing technological intervention, global antimicrobial resistance, and changing health care delivery patterns.6

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