Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
In Reply: In our study, following cerebral
arteriography and clot placement, all monkeys were randomized to control (n = 8)
or nitrite (n = 6) groups. However, after the first day of infusion
in 3 monkeys from the nitrite group, we noticed that there was no change in
blood pressure and that blood methemoglobin levels remained significantly
below toxicity levels. We therefore increased the nitrite dose in each of
these first 3 monkeys (via delivery of boluses) and also increased the dose
for the subsequent 3 monkeys in the nitrite group. Thus, all monkeys were
randomized to the different treatment modalities.
Pluta RM, Gladwin MT, Oldfield EH. Methodological Standards in Human vs Animal Clinical Trials—Reply. JAMA. 2005;294(1):40-41. doi:10.1001/jama.294.1.40-b