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July 20, 2005

Biomarkers for Mortality and Cardiovascular Events

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;294(3):303-304. doi:10.1001/jama.294.3.303-a

To the Editor: Dr Kistorp and colleagues1 determined the predictive value of 3 emerging biomarkers for total mortality and cardiovascular end points, N-amino terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP), and the albumin/creatinine ratio in urine. Studying 626 participants with mean age of 68 years from the general population without overt heart failure or renal failure, Kistorp et al found the strongest association was between NT-proBNP and these end points, followed by the albumin/creatinine ratio in urine. CRP was not independently associated with total mortality or with cardiovascular end points, and the authors concluded that CRP may not contribute to risk prediction in older nonhospitalized participants. There are 2 issues that might limit their conclusions and the generalizability of the results.

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