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July 27, 2005

Vitamin E Supplementation, Cardiovascular Events, and Cancer

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;294(4):425-426. doi:10.1001/jama.294.4.425-b

To the Editor: In 1950, Vogelsang1 reported that intramuscular administration of α-tocopherol produced rapid and dramatic diuresis in patients with severe heart failure. Dr Lonn and colleagues have now shown that long-term supplementation with α-tocopherol increases the risk of developing heart failure.2 These findings are not necessarily incompatible.

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