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July 27, 2005

Vitamin E Supplementation, Cardiovascular Events, and Cancer

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;294(4):425-426. doi:10.1001/jama.294.4.425-c

To the Editor: The article by the HOPE and HOPE-TOO trial investigators1 concludes that vitamin E supplementation does not prevent cancer or cardiovascular events when used for 7 years. Study patients had preexisting coronary or peripheral artery disease, stroke, or diabetes mellitus plus another cardiovascular disease risk factor, and the mean age was 66 years. Although it is a well-controlled investigation, its primary conclusion does not fit the study’s parameters.

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