Experiments that caused mice to quickly develop characteristics of premature
aging reveal that mutations in mitochondrial DNA may play a key role in growing
For years, mitochondria have been linked to aging. In the new findings,
researchers demonstrated that an accumulation of genetic mutations in mitochondria
sets off a cascade of signals that causes programmed cell death, or apoptosis
(Kujoth et al. Science. 2005;309:481-484). The result
is loss of irreplaceable cells and progression of aging.
Hampton T. Study Reveals Mitochondrial Role in Aging. JAMA. 2005;294(6):672. doi:10.1001/jama.294.6.672