[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.176.35. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Medical News and Perspectives
August 10, 2005

Study Reveals Mitochondrial Role in Aging

JAMA. 2005;294(6):672. doi:10.1001/jama.294.6.672

Experiments that caused mice to quickly develop characteristics of premature aging reveal that mutations in mitochondrial DNA may play a key role in growing old.

For years, mitochondria have been linked to aging. In the new findings, researchers demonstrated that an accumulation of genetic mutations in mitochondria sets off a cascade of signals that causes programmed cell death, or apoptosis (Kujoth et al. Science. 2005;309:481-484). The result is loss of irreplaceable cells and progression of aging.

First Page Preview View Large
First page PDF preview
First page PDF preview
×