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Grand Rounds
Clinician's Corner
September 14, 2005

Tumor-Induced Osteomalacia

Author Affiliations
 

Grand Rounds Section Editor: David S. Cooper, MD, Contributing Editor, JAMA.

 

Author Affiliation: Department of Medicine, Johns Hopkins University School of Medicine, and Department of Endocrinology, Johns Hopkins Bayview Medical Center, Baltimore, Md.

JAMA. 2005;294(10):1260-1267. doi:10.1001/jama.294.10.1260
Abstract

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia. This debilitating disorder is illustrated by the clinical presentation of a 55-year-old woman with progressive fatigue, weakness, and muscle and bone pain with fractures. After a protracted clinical course and extensive laboratory evaluation, tumor-induced osteomalacia was identified as the basis of her clinical presentation. In this article, the distinctive clinical characteristics of this syndrome, the advances in diagnosis of TIO, and new insights into the pathophysiology of this disorder are discussed.

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