Author Affiliations: Center for Medical Ethics
and Health Policy, Baylor College of Medicine, Houston, Tex.
An international consensus for protecting the rights and interests of
research subjects has emerged in a process that began with the Declaration
of Helsinki1 and continues in the development
of official guidelines2 as well as a growing
scholarly literature.3 Despite this consensus,
legitimate ethical controversies persist. This article discusses points of
consensus and controversy in clinical research ethics, focusing on substantive,
rather than procedural, concerns.
Brody BA, McCullough LB, Sharp RR. Consensus and Controversy in Clinical Research Ethics. JAMA. 2005;294(11):1411-1414. doi:10.1001/jama.294.11.1411