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September 28, 2005

Electrocardiographic Effects of a Dietary Supplement Containing Ephedra and Caffeine—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;294(12):1487-1488. doi:10.1001/jama.294.12.1487-b

In Reply: As noted by Dr Milic and colleagues, we used the incorrect formula taken from the article by Moss.1 We have recalculated our results using the correct formula for linear corrected QTc intervals. When the Framingham Linear Correction is properly used, the differences in the postdosing QTc interval values between the DSEC and placebo groups are of the same magnitude and direction as those derived from the Bazett formula (20.3-millisecond increase with DSEC; 400.5 milliseconds [SD, 10.7] vs 380.2 milliseconds [SD, 15.3]; P<.001).

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