October 19, 2005

Antipsychotic Drugs in DementiaWhat Should Be Made of the Risks?

Author Affiliations

Author Affiliations: Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Md.

JAMA. 2005;294(15):1963-1965. doi:10.1001/jama.294.15.1963

The introduction of the first antipsychotic drug, chlorpromazine, into clinical practice more than 50 years ago revolutionalized psychiatry and neurology.1 The efficacy of this drug and other drugs in the phenothiazine class demonstrated that a disease considered a “mental illness” could respond to a biologically mediated therapy and heralded the introduction of other neuromodulating therapies such as levodopa for Parkinson disease.

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