Author Affiliations: Department of Psychiatry
and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Md.
The introduction of the first antipsychotic drug, chlorpromazine, into
clinical practice more than 50 years ago revolutionalized psychiatry and neurology.1 The efficacy of this drug and other drugs in the phenothiazine
class demonstrated that a disease considered a “mental illness”
could respond to a biologically mediated therapy and heralded the introduction
of other neuromodulating therapies such as levodopa for Parkinson disease.
Rabins PV, Lyketsos CG. Antipsychotic Drugs in DementiaWhat Should Be Made of the Risks?. JAMA. 2005;294(15):1963-1965. doi:10.1001/jama.294.15.1963