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Medical News and Perspectives
October 19, 2005

Genetic Flaws Found in Aging Stem Cell Lines

JAMA. 2005;294(15):1883-1884. doi:10.1001/jama.294.15.1883

New research has provided evidence that human embryonic stem cells grown in culture accumulate changes in their genetic material over time that might limit the usefulness of aging stem cell lines.

Using new and highly sensitive array technology, an international team of researchers has identified alterations in chromosomes and certain genes occurring over time in federally approved stem cell lines. Epigenetic changes, which are changes involving factors within a cell that can change the cell’s phenotype without altering its genotype, in the cell lines were also identified. These findings by Maitra et al were published September 4 in the journal Nature Genetics (http://www.nature.com/ng/journal/vaop/ncurrent/index.html.html).

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