New research has provided evidence that human embryonic stem cells grown
in culture accumulate changes in their genetic material over time that might
limit the usefulness of aging stem cell lines.
Using new and highly sensitive array technology, an international team
of researchers has identified alterations in chromosomes and certain genes
occurring over time in federally approved stem cell lines. Epigenetic changes,
which are changes involving factors within a cell that can change the cell’s
phenotype without altering its genotype, in the cell lines were also identified.
These findings by Maitra et al were published September 4 in the journal Nature Genetics (http://www.nature.com/ng/journal/vaop/ncurrent/index.html.html).
Kuehn BM. Genetic Flaws Found in Aging Stem Cell Lines. JAMA. 2005;294(15):1883-1884. doi:10.1001/jama.294.15.1883