Author Affiliations: Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia (Drs Wainwright and Grimwood) (firstname.lastname@example.org); and Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia (Dr Carlin).
In Reply: We agree with Drs Linnane and McNally that our study would have been flawed had we only collected BAL samples after a positive oropharyngeal culture for P aeruginosa in infants and preschool children with cystic fibrosis. However, we also obtained BAL samples at baseline when infants were stable clinically, during hospitalization for respiratory exacerbations, and after completing a treatment course for eradication of P aeruginosa.
Wainwright CE, Carlin JB, Grimwood K. Bronchoalveolar Lavage–Directed Therapy in Children With Cystic Fibrosis and Pseudomonas aeruginosa Infection—Reply. JAMA. 2011;306(16):1761-1762. doi:10.1001/jama.2011.1519