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Letters
October 26, 2011

Bronchoalveolar Lavage–Directed Therapy in Children With Cystic Fibrosis and Pseudomonas aeruginosa Infection—Reply

Author Affiliations

Author Affiliations: Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia (Drs Wainwright and Grimwood) (claire_wainwright@health.qld.gov.au); and Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia (Dr Carlin).

JAMA. 2011;306(16):1761-1762. doi:10.1001/jama.2011.1519

In Reply: We agree with Drs Linnane and McNally that our study would have been flawed had we only collected BAL samples after a positive oropharyngeal culture for P aeruginosa in infants and preschool children with cystic fibrosis. However, we also obtained BAL samples at baseline when infants were stable clinically, during hospitalization for respiratory exacerbations, and after completing a treatment course for eradication of P aeruginosa.

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