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October 26, 2005

Mechanical Reperfusion More Than 12 Hours After Acute Myocardial Infarction—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;294(16):2030-2032. doi:10.1001/jama.294.16.2031-b

In Reply: Drs Rubin and Warner are concerned that no cardiac biomarkers were used to assess time delay to presentation for the patients with acute STEMI included in the BRAVE-2 trial. The goal of the BRAVE 2 trial was to assess whether an invasive strategy is associated with reduction of infarct size in patients with STEMI presenting more than 12 hours after symptom onset. The study was based on symptoms and unequivocal electrocardiographic changes to define acute MI, and on the interval from symptom onset to define time to presentation.

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