Letters Section Editor: Robert M. Golub, MD, Senior Editor.
In Reply: Dr Dhatariya has pointed out that there is evidence for de novo biosynthesis of DHEA within the brain1 and that peripheral levels of DHEAS may not reflect brain tissue concentrations. The intention of our study was to highlight that the biosynthesis and metabolism of C19 steroids is complex and that measurement of circulating androgens and pre-androgens does not necessarily provide an accurate guide to the hormonal milieu in different target tissues.
Davis SR, Davison SL, Donath S, Bell RJ. Self-reported Sexual Function in Women and Androgen Levels—Reply. JAMA. 2005;294(17):2167-2168. doi:10.1001/jama.294.17.2168-a