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November 2, 2005

Parvovirus B19 and Onset of Juvenile Dermatomyositis

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;294(17):2165-2171. doi:10.1001/jama.294.17.2170

To the Editor: Juvenile dermatomyositis (JDM) is a systemic autoimmune disease characterized by chronic muscle and cutaneous inflammation of unknown cause; however, some studies have suggested that infectious agents may trigger the onset of JDM and other childhood systemic autoimmune diseases.1 Several studies have described the detection of parvovirus B19 DNA in skin or muscle of patients with JDM, adult dermatomyositis, and other systemic rheumatic diseases.2 Given the similarity of the disease presentation of JDM and parvovirus B19 infection, we performed a case-control study to determine if parvovirus B19 infection is associated with the onset of JDM.

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