Author Affiliations: Office of Antimicrobial Resistance, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga.
The problem of antimicrobial resistance has been evident almost from the time antimicrobial drugs entered the pharmacopoeia. However, the clinical impact of resistance has been difficult to measure for a variety of reasons, including separating out the effect of underlying illness and the availability of at least 1 effective drug for most infections. Antimicrobial resistance also has economic consequences, but even those have been difficult to quantify.1 Nevertheless, the decrease in new drug development and increasing resistance to multiple drug classes among various infections require effective interventions now to mitigate the inevitable increase in morbidity and mortality.
Weber JT. Appropriate Use of Antimicrobial DrugsA Better Prescription Is Needed. JAMA. 2005;294(18):2354-2356. doi:10.1001/jama.294.18.2354