Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: Dr Moses-Kolko and colleagues1 reviewed the literature on neonatal signs after late in utero exposure to selective serotonin reuptake inhibitors (SSRIs). We are concerned about a statement in their conclusions regarding the similarity of neonatal behavioral syndrome to infantile colic. The 2 syndromes should be easily distinguishable clinically. Neonatal behavioral syndrome has an earlier onset, ends earlier (usually by 2-3 weeks, the time that typical infantile colic begins), and, in most cases, does not show the same pattern of fussy behavior confined to a certain time of day.2 Moreover, colicky infants generally do not exhibit the other signs associated with neonatal behavioral syndrome, such as neurological, respiratory, and gastrointestinal disturbances.1
Kaye BA, Weinstein J. Neonatal Signs After In Utero Exposure to Selective Serotonin Reuptake Inhibitors. JAMA. 2005;294(18):2299-2301. doi:10.1001/jama.294.18.2299-c