Author Affiliations: Department of Medicine and Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego; Veterans Administration Research Service, San Diego.
In any classic “whodunit” mystery, the goal of the investigator is to find and expose the guilty party. At the onset, there may be many suspects, some of whom may appear guilty. However, the shrewd investigator picks through those distractors to clearly eliminate them and focuses on specific details to finally identify the true culprit. The same approach holds for the recognition of the hamartomatous polyposis syndromes, many of which demonstrate phenotypic features that overlap with each other.
Carethers JM. Unwinding the Heterogeneous Nature of Hamartomatous Polyposis Syndromes. JAMA. 2005;294(19):2498-2500. doi:10.1001/jama.294.19.2498