[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.179.146. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Editorial
November 16, 2005

The IDEAL CholesterolLower Is Better

Author Affiliations
 

Author Affiliations: TIMI Study Group, Cardiovascular Division, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass.

JAMA. 2005;294(19):2492-2494. doi:10.1001/jama.294.19.2492

Three decades ago, the primary results of the Multiple Risk Factor Intervention Trial (MRFIT) were published in JAMA; that trial attempted to demonstrate benefits from lowering cholesterol (with diet) and managing other known risk factors for reducing cardiovascular morbidity and mortality.1 Since then, multiple trials have shown cardiovascular benefit from lowering cholesterol, especially low-density lipoprotein cholesterol (LDL-C).2,3 However, as of 1993, no trial had demonstrated a clear reduction in total mortality and, thus, debate still raged as to whether it was beneficial to reduce cholesterol.3

First Page Preview View Large
First page PDF preview
First page PDF preview
×