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The World in Medicine
November 16, 2005

Drug-Resistant Avian Flu

JAMA. 2005;294(19):2423. doi:10.1001/jama.294.19.2423-a

A report last month from researchers in Vietnam, Japan, and the United States suggests that drug resistance may be emerging in H5N1 avian influenza virus, heightening concerns about preparedness for a potential pandemic (Le et al. Nature. 2005;437:1108).

The virus was isolated from a Vietnamese teenager who had been treated with prophylactic doses of oseltamivir, a neuraminidase inhibitor currently used for protection against and treatment for influenza, including H5N1 avian influenza. The girl was subsequently treated with higher doses of the drug and recovered.

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