Author Affiliations: Division of Radiation Oncology, Northwestern University, Chicago, Ill (Dr Small); Department of Radiation Oncology, Boston University Medical Center, Boston, Mass (Dr Kachnic).
Radiotherapy has proven to be an indispensable tool in the curative management of malignant disease, especially for primary carcinomas of the pelvis including prostate, rectal, cervical, endometrial, and anal cancers. In this setting, radiotherapy is used either alone or in combination with systemic, hormonal, and/or surgical therapies. The ultimate goal of this radiation-based therapy is to provide long-term disease control or a “cure” with as little treatment-related morbidity as possible. Yet, the study of long-term toxicity associated with treatments that include radiation therapy has received little attention over the years.
Small W, Kachnic L. Postradiotherapy Pelvic FracturesCause for Concern or Opportunity for Future Research?. JAMA. 2005;294(20):2635-2637. doi:10.1001/jama.294.20.2635