Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: Dr Ridker and colleagues1 report that, in a large subgroup of participants in the Women's Health Study, apolipoproteins B and A-I offer no advantage over non–high-density lipoprotein (HDL) cholesterol and the ratio of total cholesterol to HDL cholesterol in the prediction of future cardiovascular events. However, the generalizability of their conclusions is threatened by their use of a low-risk population and by the difference between the predictive accuracy of variables within a total group and the predictive accuracy of variables within distinct subgroups.
Sniderman AD. Risk Factors for Cardiovascular Disease in Women. JAMA. 2005;294(22):2843-2844. doi:10.1001/jama.294.22.2843-b