Letters Section Editor: Robert M. Golub, MD, Senior Editor.
In Reply: We agree with Dr Manfredini and colleagues that morning-night variation and circadian rhythms might influence outcomes for patients with myocardial infarction. Future investigations should examine these issues as well as whether the effectiveness of percutaneous coronary intervention shows a circadian variation.
Magid DJ, Bradley EH, Krumholz HM. Circadian Rhythms and Reperfusion in Patients With Acute ST-Segment Elevation Myocardial Infarction—Reply. JAMA. 2005;294(22):2846-2847. doi:10.1001/jama.294.22.2847-a