While chromosomal translocations resulting in fused genes have been found in various types of leukemias, lymphomas, and sarcomas, few have been documented in most types of solid cancers. But now a chromosomal rearrangement has been implicated as a potential cause of some prostate cancers, a finding that could lead to new diagnostic and therapeutic strategies (Tomlins et al. Science. 2005;310:644-648).
The findings come through the use of a research tool called Oncomine, a collection of data from numerous cancer studies across the globe, studies that use devices called microarrays to simultaneously screen the activity of thousands of genes (Hampton. JAMA. 2004;292:2073). The collection integrates 132 gene expression data sets representing 10 486 microarray experiments.
Hampton T. Gene Fusion Found in Prostate Cancer. JAMA. 2005;294(22):2832. doi:10.1001/jama.294.22.2832