Letters Section Editor: Robert M. Golub, MD, Senior Editor.
In Reply: Dr Trainer raises questions related to the differences between biopsy-derived and prostatectomy-derived Gleason scores in our study. The pathological specimens, from both biopsy and radical prostatectomy, were read by the same team of pathologists during the entire study period, not by a single pathologist. However, we agree that differences between biopsy and radical prostatectomy grading are well documented.1,2
Freedland SJ, Humphreys EB, Mangold LA, Partin AW, Eisenberger M, Dorey FJ. Mortality Following Prostate Cancer Recurrence After Radical Prostectomy—Reply. JAMA. 2005;294(23):2969-2970. doi:10.1001/jama.294.23.2969-b