Author Affiliations: Division of Infectious
Diseases (Drs Weinstock and Zuccotti) and Division of Blood and Marrow Transplantation
(Dr Weinstock), Department of Medicine, Memorial Sloan-Kettering Cancer Center,
New York, NY. Dr Zuccotti is also Contributing Editor, JAMA.
Published online February 2, 2006 (doi:10.1001/jama.295.8.jed60009).
The global burden of influenza infection is staggering. In a typical
year, approximately 20% of the world's population is infected and more than
a half million individuals die of influenza-associated complications.1 During influenza pandemics, morbidity and mortality
are catastrophic—20 million to 100 million individuals died in the 1918
influenza pandemic, 2 million in the 1955 pandemic, and 1 million in the 1968
Weinstock DM, Zuccotti G. Adamantane Resistance in Influenza A. JAMA. 2006;295(8):934-936. doi:10.1001/jama.295.8.jed60009