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February 22, 2006

Growth Hormone for “Antiaging”

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(8):888-890. doi:10.1001/jama.295.8.889-a

To the Editor: We disagree with the arguments put forward in the Commentary by Dr Perls and colleagues1 to oppose the widespread use of GH replacement for elderly GH deficiency (GHD). First, the authors suggest that GH replacement is associated with substantial adverse effects. Wuster et al demonstrated that such adverse effects may be due to overdosing and can be avoided by reducing the dose of GH by 50%.2

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