March 22/29, 2006

Maternal X Chromosome, Visceral Adiposity, and Lipid Profile

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(12):1373-1378. doi:10.1001/jama.295.12.1373

To the Editor: Men typically have more visceral fat and atherogenic plasma lipids than women,1 contributing to an increased risk of ischemic heart disease. This pattern has been attributed to sex steroids, but other factors may be important. A disparity in X chromosome gene expression may influence sex-specific differences in lipid metabolism and coronary artery disease.2

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