Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: Men typically have more visceral fat and atherogenic plasma lipids than women,1 contributing to an increased risk of ischemic heart disease. This pattern has been attributed to sex steroids, but other factors may be important. A disparity in X chromosome gene expression may influence sex-specific differences in lipid metabolism and coronary artery disease.2
Van PL, Bakalov VK, Zinn AR, Bondy CA. Maternal X Chromosome, Visceral Adiposity, and Lipid Profile. JAMA. 2006;295(12):1373-1378. doi:10.1001/jama.295.12.1373