Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: We recently reported that insulin resistance is an independent predictor of congestive heart failure (CHF).1 In a subsequent Letter to the Editor, Stefan et al2 proposed adiponectin as a mediator of that association. Low adiponectin concentration has been associated with risk of myocardial infarction.3 We therefore investigated in our cohort (Uppsala Longitudinal Study of Adult Men) whether circulating adiponectin (primary hypothesis) or single nucleotide polymorphisms (SNPs) in the adiponectin gene ADIPOQ (secondary hypothesis) predict incident CHF.
Ingelsson E, Risérus U, Berne C, Frystyk J, Flyvbjerg A, Axelsson T, Lundmark P, Zethelius B. Adiponectin and Risk of Congestive Heart Failure. JAMA. 2006;295(15):1769-1774. doi:10.1001/jama.295.15.1772-c